A group of friends pays a late-night visit to the city morgue to surprise Amy (Harris) on her birthday. But the surprise is on them when the one-eyed corpse of brutal psychopath Jacob Goodnight (Jacobs) unexpectedly rises from a cold sub-basement slab. Their wild party quickly turns into a terrifying slay-fest as the sadistic mass-murderer resumes his savage rampage complete with hooks, surgical knives and power saws.

While investigating a call in an abandoned house, Officer Frank Williams and a rookie find a woman brutally blinded, but they are attacked by a huge psychopath with an ax; the rookie is killed and Frank shots the criminal in the head, but has a severed arm. Four years later, the mutilated Frank is relocated, working as a guard in the County Detention Center. Frank goes with some delinquents to the Blackwell Hotel, an abandoned place since a fire burnt the last two floors, with the purpose of cleaning the location, preparing it to work as a shelter for homeless; in return, the criminals will have their sentences reduced. During the night, the inmate Kira that has some Christian tattoos in her body is kidnapped by the deranged serial-killer Kane that collect the eyes of his victims, while the rest of the group is attacked by the psychopath with his ax.